PO-01-194 A COMPARISON OF CLINICAL OUTCOMES FOR THREE DIFFERENT MODALITIES USED FOR PULMONARY VEIN ISOLATION IN PATIENTS WITH ATRIAL FIBRILLATION

Pulmonary Vein Isolation (PVI) represents the cornerstone in atrial fibrillation ablation. The two most frequently used technologies for PVI are radiofrequency (RF) and cryoablation (CB). More recently, laser balloon (LB) has emerged as a promising therapy. Studies comparing all three modalities lacking. We sought to compare clinical outcomes of RF, CB, LB ablation patients with from prospective multi center registry. Between January 2018 December 2021 912 3 U.S. centers underwent catheter either or LB. Baseline characteristic procedural data were obtained (table). Patients followed 1 year. primary outcome was time fibrillation. Secondary any arrythmia anti-arrhythmic drug therapy after 90-day blanking period. A total enrolled during study. There no significant differences at baseline between groups regards sex, age, prior cardiac history. 331 (36%) 227 (25%) LB, 354 (39%) RF. difference recurrence across treatment 180 days (p=0.635) 360 (p=0.425) (Figure). After there trend towards less arrythmias group vs CB (p=0.096). Time use AADs period significantly higher RF (p=0.009). In cohort, associated severe LA dilation [HR 1.841 (95%CI 1.044 3.247); p=0.035] paroxysmal type AF 0.66 (95% CI 0.45 0.98); p=0.038]. common complication groin hematoma. No atrioesophageal fistulae observed. Death occurred one patient unrelated procedure. this cohort study, similar lower arrhythmia year compared group. who more likely be initiated on AAD Predictors included severely enlarged AF. Similar rates complications seen groups.Tabled 1Patient CharacteristicsCharacteristicOverallCryo, NLaser, NRF, Np-valueAge656566650.3Male Sex5572311861400.051Hypertension6812391652770.12Diabetes2006353840.3Coronary artery disease1926452760.6Stroke662511300.2Congestive heart failure168121128135<0.001AAD therapy4191391101700.6Procedure (min)126121128135<0.001Vascular complications30030.12Post stroke1003>0.9Phrenic nerve palsy72410.13Hematoma3085170.11Death10110.2 Open table new tab